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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - UNC926 hydrochloride

UNC926 hydrochloride

CAS No. 1782573-49-2

UNC926 hydrochloride( —— )

Catalog No. M23797 CAS No. 1782573-49-2

UNC926 hydrochloride is a?methyl-lysine (Kme) reader domain?inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UNC926 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC926 hydrochloride is a?methyl-lysine (Kme) reader domain?inhibitor.
  • Description
    UNC926 hydrochloride is a?methyl-lysine (Kme) reader domain?inhibitor.
  • In Vitro
    UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    L3MBTL1|L3MBTL3|L3MBTL4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1782573-49-2
  • Formula Weight
    373.72
  • Molecular Formula
    C16H22BrClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL?(444.77 mM)
  • SMILES
    O=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Herold JM, et al. Structure-activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45-51.
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