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UNC926 hydrochloride
CAS No. 1782573-49-2
UNC926 hydrochloride( —— )
Catalog No. M23797 CAS No. 1782573-49-2
UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 272 | In Stock |
|
| 10MG | 408 | In Stock |
|
| 25MG | 672 | In Stock |
|
| 50MG | 945 | In Stock |
|
| 100MG | 1278 | In Stock |
|
| 500MG | 2547 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUNC926 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionUNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
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DescriptionUNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
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In VitroUNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorL3MBTL1|L3MBTL3|L3MBTL4
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Research Area——
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Indication——
Chemical Information
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CAS Number1782573-49-2
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Formula Weight373.72
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Molecular FormulaC16H22BrClN2O
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL?(444.77 mM)
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SMILESO=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Herold JM, et al. Structure-activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45-51.
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